Encyclopedia entry · GH Secretagogues
Hexarelin
Hexarelin is a synthetic hexapeptide ghrelin mimetic. It acts on the same GHSR receptor as Ipamorelin and the GHRP family, but with a stronger pharmacological profile and more pronounced cortisol and prolactin side-effects in the preclinical work. Cardiovascular effects via CD36 receptor activity are a distinct research interest.
What the molecule is
- · Six-amino-acid synthetic peptide (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2).
- · Ghrelin-receptor (GHSR) agonist.
- · Also reported activity at the CD36 cardiac receptor in preclinical work.
- · Researched both for GH-release potency and for direct cardioprotective effects independent of GH.
What the literature shows
- · Stronger GH release than Ipamorelin in preclinical comparisons.
- · Higher cortisol and prolactin elevation than Ipamorelin in published work.
- · Cardioprotection in rodent ischaemia-reperfusion injury models via CD36 pathway.
- · Receptor desensitisation observed with chronic dosing in rodent models.
UK regulatory status
- · Not a controlled drug under the Misuse of Drugs Act 1971.
- · Not scheduled under the Psychoactive Substances Act 2016.
- · No UK marketing authorisation as a medicine.
- · Research-use-only framing required for UK sale.
Where UK researchers source Hexarelin
See CoA Trust Index →Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list Hexarelin or compounds in the same category. We earn a referral fee when readers click through and convert.
Researchers wanting named-stack bundles (Wolverine, KLOW, Glow) and CoAs that can be QR-verified to a named third-party lab.
Research peptide retailer · Wolverine Stack £29.99, BPC-157 single from £14.99
Nottingham-based research peptide retailer (Bio Research Ltd, since 2024). Bundles and stacks are the hero SKU (Wolverine BPC-157 + TB-500, Tesamorelin + Ipamorelin 3:1, KLOW, Glow). Janoshik third-party CoAs published per batch with QR-code verification. 10-vial bulk packs alongside singles. Wholesale tier above 11 vials.
Best for per-batch CoA library
Research peptide retailer · BPC-157 5mg £13.99, TB-500 5mg £36
Long-established UK research peptide supplier. 12 years trading, 15,000+ customers. Operates a public CoA subdomain (coa.purepeptidesuk.com) with downloadable per-batch certificates linked from every PDP. Dual-tier purity (Standard vs Premium with endotoxin LAL + heavy-metal testing on Premium).
Researchers who want transparent third-party HPLC batch documents and a less hyped brand voice.
Research peptide retailer · Per peptide, varies
UK research peptide retailer with third-party HPLC plus transparent batch documentation. Plays the credibility lane alongside Pure Peptides UK and Tide Labs.
Researchers who weight UKAS lab accreditation specifically and want the loudest external-verification claim in the segment.
Research peptide retailer · Per peptide, varies
UK research peptide retailer leaning on UKAS-verified HPLC as the sole-in-UK trust claim. Narrower catalogue than UKPeptides or Pure Peptides UK but the lab-verification angle is the loudest in the segment.
Best for classic peptides catalogue
Research peptide retailer · Per peptide, varies
Long-trading UK research peptide retailer (2012). Heavy on classic compounds (BPC-157, TB-500, GHK-Cu, CJC-1295, Ipamorelin, MOTS-c). No GLP-1, no cosmetic line. CoA gated via on-site contact form (request lab report per product). On-site CusRev reviews 5.0 average, not Trustpilot. Reconstitution calculator on-site.
Buyers who want personal owner-accountability via WhatsApp and prefer CoAs visible in product images rather than gated. Strong stack catalogue.
Research peptide retailer · BPC-157 from £18.99, Wolverine Stack discounted
Family-run Newcastle research peptide retailer (Rian, Victoria, Leah Redman). Owner-fronted WhatsApp on every page. CoAs photographed into the product gallery (COA in image) rather than gated. Heavy on named-stack bundles (Wolverine, Hulk, Ultimate Bundle). Crisp live chat sitewide. Personal accountability is the trust play.
Where to learn more
- · PubMed search: "Hexarelin GH" and "Hexarelin CD36".
- · Reviews by Ghigo E et al. on ghrelin-mimetic pharmacology.
- · Our function hub: GH Secretagogues.
PeptideClear does not sell, dispense, prescribe, or recommend Hexarelin for any specific person. This page is editorial commentary on the published preclinical and clinical research literature and the UK retail landscape.
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UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.