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FAQ · cosmetic peptides

Cosmetic peptides FAQ

UK answers to the questions most readers ask before buying a peptide serum.

What concentration of GHK-Cu actually works in skincare?

Topical research uses 0.1% to 1% GHK-Cu. UK consumer serums typically sit in the 0.05% to 0.3% range when concentration is disclosed. Below that, you are paying for vanity dosing.

What does Matrixyl 3000 actually contain?

A branded blend by Sederma combining palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. Sederma recommends 3 to 8% of the trade ingredient, which translates to about 0.05 to 0.1% of the actual peptides.

GHK-Cu vs Matrixyl 3000, which is better?

Different mechanisms, complementary signalling. GHK-Cu has the stronger evidence base. Matrixyl 3000 has the stronger commercial recognition. If your routine has room, layer both in separate steps.

How long until I see results from a peptide serum?

Plan for 8 to 12 weeks of daily use before judging. Skin turnover is slow. Photographs at week 0, 6, 12 in consistent light are the only honest comparison.

Can I use peptides with vitamin C?

Not in the same step. Vitamin C is low pH and degrades most peptides. Use vitamin C in the morning, peptides at night, or in alternating routines.

Can I use peptides with retinol?

Yes, in separate steps. Retinol typically goes on first to bare skin, peptides after. Or alternate nights.

Are peptide serums safe in pregnancy?

Cosmetic peptides are generally considered low risk in pregnancy because absorption from skin is minimal. Speak with your doctor or midwife if you have any concerns. We are not medical advisers.

Do peptide eye creams actually do anything?

The eye area has thinner skin than the rest of the face, so peptides reach the dermis more easily. Eye-specific peptide products typically work as well or better than face serums in that region.

Can I use copper peptides every day?

Yes for most people. Copper peptides are well tolerated. Some sensitive skins prefer alternating days at first.

Which UK retailers stock the best peptide serums?

Cult Beauty has the broadest specialist range. LookFantastic and Boots cover mainstream UK. Beauty Pie has member-only pricing on its own peptide serums.

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Reviewed by Oliver Mackman, editorial director · last reviewed 2026-06-02T12:00:00.000Z
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