Encyclopedia entry
TB-500
Oliver Mackman · Editorial director · Best Business Loans Ltd (16833937)
Last updated 2026-05-20
TB-500 is a synthetic fragment of thymosin beta-4 (TB4), a naturally occurring 43-amino-acid protein. The TB-500 fragment is a 17-amino-acid peptide that retains some of the wound-healing and anti-inflammatory activity of the parent molecule. Animal data spans tendon, ligament, cardiac, and skin tissue repair. No published phase II or phase III human clinical trials.
What the literature shows (in animals)
- · Tissue repair acceleration in rat tendon, ligament, and skin wound models.
- · Anti-inflammatory effects in multiple rodent inflammation models.
- · Cardiac repair literature (Bock-Marquette group, multiple papers).
- · Hair follicle stem cell activation (Goldstein lab).
- · Independent replication better than BPC-157, with multiple groups producing consistent findings.
UK regulatory status
- · Not controlled under the Misuse of Drugs Act 1971.
- · Not scheduled under the Psychoactive Substances Act 2016.
- · No UK marketing authorisation as a medicine.
- · Sold legally as a research chemical under "research use only" framing.
- · On the WADA prohibited list (peptide hormones class). Tested athletes should be aware.
Where to learn more
- · PubMed search "thymosin beta 4" returns ~2,000 papers, most preclinical or in vitro.
- · Goldstein lab publications on tissue repair and immune modulation.
- · UK retailer comparison: research peptides UK retailers.
- · Compare to BPC-157: BPC-157 vs TB-500.
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