Encyclopedia entry · Injury Recovery
KPV
Lysine-Proline-Valine tripeptide (alpha-MSH 11-13)
KPV is the C-terminal tripeptide (Lysine-Proline-Valine) of alpha-melanocyte-stimulating hormone (alpha-MSH). Most of the anti-inflammatory activity of the full alpha-MSH molecule appears to be conserved in this 3-amino-acid fragment, making KPV a research tool for studying melanocortin anti-inflammatory pathways without the pigmentation effects of the full peptide.
What the molecule is
- · Three-amino-acid sequence: Lysine-Proline-Valine.
- · Derived from the C-terminus of alpha-MSH (residues 11-13 of the 13-residue parent peptide).
- · Retains anti-inflammatory activity of the parent alpha-MSH in preclinical models without the melanocortin-1 receptor pigmentation effects.
- · Researched both for systemic administration and for topical and oral routes.
What the literature shows
- · Anti-inflammatory effects in rodent models of ulcerative colitis and inflammatory bowel disease.
- · Reduction of mast-cell activation markers in animal allergic-response models.
- · Wound-healing effects in rodent skin-model literature.
- · Investigation alongside BPC-157 in gut-barrier preclinical work.
The literature base is smaller than BPC-157 or TB-500. Most published work originates from a handful of research groups and uses rodent models. No phase II or phase III human RCT data is published.
UK regulatory status
- · Not a controlled drug under the Misuse of Drugs Act 1971.
- · Not scheduled under the Psychoactive Substances Act 2016.
- · No UK marketing authorisation as a medicine.
- · Sold legally as a research chemical when marketed without therapeutic claims.
Where UK researchers source KPV
See CoA Trust Index →Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list KPV or compounds in the same category. We earn a referral fee when readers click through and convert.
Researchers wanting named-stack bundles (Wolverine, KLOW, Glow) and CoAs that can be QR-verified to a named third-party lab.
Research peptide retailer · Wolverine Stack £29.99, BPC-157 single from £14.99
Nottingham-based research peptide retailer (Bio Research Ltd, since 2024). Bundles and stacks are the hero SKU (Wolverine BPC-157 + TB-500, Tesamorelin + Ipamorelin 3:1, KLOW, Glow). Janoshik third-party CoAs published per batch with QR-code verification. 10-vial bulk packs alongside singles. Wholesale tier above 11 vials.
Best for per-batch CoA library
Research peptide retailer · BPC-157 5mg £13.99, TB-500 5mg £36
Long-established UK research peptide supplier. 12 years trading, 15,000+ customers. Operates a public CoA subdomain (coa.purepeptidesuk.com) with downloadable per-batch certificates linked from every PDP. Dual-tier purity (Standard vs Premium with endotoxin LAL + heavy-metal testing on Premium).
Researchers who want transparent third-party HPLC batch documents and a less hyped brand voice.
Research peptide retailer · Per peptide, varies
UK research peptide retailer with third-party HPLC plus transparent batch documentation. Plays the credibility lane alongside Pure Peptides UK and Tide Labs.
Researchers who weight UKAS lab accreditation specifically and want the loudest external-verification claim in the segment.
Research peptide retailer · Per peptide, varies
UK research peptide retailer leaning on UKAS-verified HPLC as the sole-in-UK trust claim. Narrower catalogue than UKPeptides or Pure Peptides UK but the lab-verification angle is the loudest in the segment.
Best for classic peptides catalogue
Research peptide retailer · Per peptide, varies
Long-trading UK research peptide retailer (2012). Heavy on classic compounds (BPC-157, TB-500, GHK-Cu, CJC-1295, Ipamorelin, MOTS-c). No GLP-1, no cosmetic line. CoA gated via on-site contact form (request lab report per product). On-site CusRev reviews 5.0 average, not Trustpilot. Reconstitution calculator on-site.
Buyers who want personal owner-accountability via WhatsApp and prefer CoAs visible in product images rather than gated. Strong stack catalogue.
Research peptide retailer · BPC-157 from £18.99, Wolverine Stack discounted
Family-run Newcastle research peptide retailer (Rian, Victoria, Leah Redman). Owner-fronted WhatsApp on every page. CoAs photographed into the product gallery (COA in image) rather than gated. Heavy on named-stack bundles (Wolverine, Hulk, Ultimate Bundle). Crisp live chat sitewide. Personal accountability is the trust play.
Where to learn more
- · PubMed search: "KPV peptide" and "alpha-MSH 11-13".
- · Brzoska T et al. reviews on melanocortin anti-inflammatory action.
- · Our function hub: Injury Recovery peptides.
- · CoA Trust Index for UK retailer documentation.
PeptideClear does not sell, dispense, prescribe, or recommend KPV for any specific person. This page is editorial commentary on the published preclinical and clinical research literature and the UK retail landscape.
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UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.