Encyclopedia entry · Longevity
5-Amino-1MQ
5-Amino-1-methylquinolinium iodide
5-Amino-1MQ is a small molecule, not a peptide, but is widely stocked by UK research peptide retailers in the longevity category. It is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that depletes the NAD+ precursor pool in adipose tissue and other organs. NNMT activity rises with age and obesity, and its inhibition is a research target for metabolic ageing.
What the molecule is
- · Small molecule (5-amino-1-methylquinolinium iodide), not a peptide.
- · Selective NNMT (nicotinamide N-methyltransferase) inhibitor.
- · NNMT inhibition preserves the cellular NAD+ precursor pool.
- · Orally bioavailable in preclinical work.
What the literature shows
- · Reduction of adipose tissue NNMT activity in mouse obesity models.
- · Weight loss and fat-mass reduction in diet-induced obese mice.
- · Muscle stem-cell preservation and improved muscle regeneration in aged mouse models.
- · NAD+ pool preservation in adipose tissue measured directly.
UK regulatory status
- · Not a controlled drug under the Misuse of Drugs Act 1971.
- · Not scheduled under the Psychoactive Substances Act 2016.
- · No UK marketing authorisation as a medicine.
- · Research-use-only framing required for UK sale.
Where UK researchers source 5-Amino-1MQ
See CoA Trust Index →Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list 5-Amino-1MQ or compounds in the same category. We earn a referral fee when readers click through and convert.
Researchers wanting named-stack bundles (Wolverine, KLOW, Glow) and CoAs that can be QR-verified to a named third-party lab.
Research peptide retailer · Wolverine Stack £29.99, BPC-157 single from £14.99
Nottingham-based research peptide retailer (Bio Research Ltd, since 2024). Bundles and stacks are the hero SKU (Wolverine BPC-157 + TB-500, Tesamorelin + Ipamorelin 3:1, KLOW, Glow). Janoshik third-party CoAs published per batch with QR-code verification. 10-vial bulk packs alongside singles. Wholesale tier above 11 vials.
Best for per-batch CoA library
Research peptide retailer · BPC-157 5mg £13.99, TB-500 5mg £36
Long-established UK research peptide supplier. 12 years trading, 15,000+ customers. Operates a public CoA subdomain (coa.purepeptidesuk.com) with downloadable per-batch certificates linked from every PDP. Dual-tier purity (Standard vs Premium with endotoxin LAL + heavy-metal testing on Premium).
Researchers who want transparent third-party HPLC batch documents and a less hyped brand voice.
Research peptide retailer · Per peptide, varies
UK research peptide retailer with third-party HPLC plus transparent batch documentation. Plays the credibility lane alongside Pure Peptides UK and Tide Labs.
Researchers who weight UKAS lab accreditation specifically and want the loudest external-verification claim in the segment.
Research peptide retailer · Per peptide, varies
UK research peptide retailer leaning on UKAS-verified HPLC as the sole-in-UK trust claim. Narrower catalogue than UKPeptides or Pure Peptides UK but the lab-verification angle is the loudest in the segment.
Best for classic peptides catalogue
Research peptide retailer · Per peptide, varies
Long-trading UK research peptide retailer (2012). Heavy on classic compounds (BPC-157, TB-500, GHK-Cu, CJC-1295, Ipamorelin, MOTS-c). No GLP-1, no cosmetic line. CoA gated via on-site contact form (request lab report per product). On-site CusRev reviews 5.0 average, not Trustpilot. Reconstitution calculator on-site.
Buyers who want personal owner-accountability via WhatsApp and prefer CoAs visible in product images rather than gated. Strong stack catalogue.
Research peptide retailer · BPC-157 from £18.99, Wolverine Stack discounted
Family-run Newcastle research peptide retailer (Rian, Victoria, Leah Redman). Owner-fronted WhatsApp on every page. CoAs photographed into the product gallery (COA in image) rather than gated. Heavy on named-stack bundles (Wolverine, Hulk, Ultimate Bundle). Crisp live chat sitewide. Personal accountability is the trust play.
Where to learn more
- · PubMed search: "5-Amino-1MQ" and "NNMT inhibitor adipose".
- · Neelakantan H et al. on NNMT inhibitor pharmacology.
- · Our function hub: Longevity peptides.
PeptideClear does not sell, dispense, prescribe, or recommend 5-Amino-1MQ for any specific person. This page is editorial commentary on the published preclinical and clinical research literature and the UK retail landscape.
Read our full methodology and how we are funded.
Ready to buy
Buy 5-AMINO-1MQ in the UK
UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.