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GHK-Cu vs Matrixyl: video explainer with transcript0:58 Watch on YouTube Read transcript

GHK-Cu vs Matrixyl: video explainer with transcript

GHK-Cu versus Matrixyl 3000. Watch the full video above, or read the complete timestamped transcript below.

Transcript

[0:00] GHK-Cu versus Matrixyl 3000. Two of the most stocked cosmetic peptides on UK shelves. How does the evidence compare?

[0:09] GHK-Cu is a copper binding tripeptide, glycyl histidyl lysine plus copper. It was discovered in human plasma by Loren Pickart in 1973. It is the most published cosmetic peptide. Topical research covers collagen synthesis, skin barrier, and antioxidant activity.

[0:19] Matrixyl 3000 is a Sederma trade name combining two peptides, palmitoyl tripeptide one and palmitoyl tetrapeptide seven. Published research focuses on the appearance of wrinkles and skin firmness endpoints in controlled studies.

[0:28] Both sit in UK cosmetic regulation, not medicines regulation. Both appear in serums stocked at Cult Beauty, Look Fantastic, Space NK, and Boots. Concentrations vary widely between brands and rarely match the percentages used in the published research.

[0:38] Full evidence breakdown on peptideclear.co.uk/vs/ghk-cu-vs-matrixyl.

[0:47] Full evidence breakdown on peptideclear.co.uk.

Not medical advice. PeptideClear is editorial commentary only. Always consult a UK-registered healthcare professional.

Reviewed by Oliver Mackman, editorial director · last reviewed 2026-07-18T12:00:00.000Z
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