Named peptide stack · Longevity
Longevity Stack
The Longevity Stack targets mitochondrial function and the pineal-pituitary axis. Typical composition: Epitalon (Russian-research tetrapeptide), MOTS-c (mitochondrial-derived peptide), and NAD+ (coenzyme, not a peptide). All three are sold by UK research peptide retailers under research-use-only framing.
Why researchers pair these compounds
Longevity-research peptides sit at the intersection of mitochondrial biology, telomere regulation, and NAD+ metabolism. None of these compounds is a UK-licensed longevity medicine. The literature is preclinical and (for Epitalon) historical Russian work that has not been independently replicated in Western trials.
Epitalon contributes the pineal-axis lineage. MOTS-c contributes the mitochondrial-derived-peptide lineage. NAD+ contributes the coenzyme-restoration angle. The three are mechanistically distinct.
CoA documentation is particularly important for Epitalon because counterfeit risk is high for less common research compounds.
Mechanism
Epitalon regulates pineal-pituitary axis activity in Russian preclinical work. MOTS-c modulates AMPK and insulin sensitivity via mitochondrial signalling. NAD+ restores the cellular NAD+ pool used by sirtuins and PARPs.
Components
Epitalon
Russian-research tetrapeptide. Four decades of pineal-axis preclinical literature.
Encyclopedia entryWho this is for
- · Researchers studying ageing-related mitochondrial decline in preclinical work.
- · Buyers evaluating the three primary longevity-research lanes.
UK retailers stocking the components
See CoA Trust Index →Ranked by CoA Trust tier. Editorial commentary based on publicly available information. We earn a referral fee when readers click through and convert.
Researchers wanting named-stack bundles (Wolverine, KLOW, Glow) and CoAs that can be QR-verified to a named third-party lab.
Research peptide retailer · Wolverine Stack £29.99, BPC-157 single from £14.99
Nottingham-based research peptide retailer (Bio Research Ltd, since 2024). Bundles and stacks are the hero SKU (Wolverine BPC-157 + TB-500, Tesamorelin + Ipamorelin 3:1, KLOW, Glow). Janoshik third-party CoAs published per batch with QR-code verification. 10-vial bulk packs alongside singles. Wholesale tier above 11 vials.
Best for per-batch CoA library
Research peptide retailer · BPC-157 5mg £13.99, TB-500 5mg £36
Long-established UK research peptide supplier. 12 years trading, 15,000+ customers. Operates a public CoA subdomain (coa.purepeptidesuk.com) with downloadable per-batch certificates linked from every PDP. Dual-tier purity (Standard vs Premium with endotoxin LAL + heavy-metal testing on Premium).
Researchers who want transparent third-party HPLC batch documents and a less hyped brand voice.
Research peptide retailer · Per peptide, varies
UK research peptide retailer with third-party HPLC plus transparent batch documentation. Plays the credibility lane alongside Pure Peptides UK and Tide Labs.
Researchers who weight UKAS lab accreditation specifically and want the loudest external-verification claim in the segment.
Research peptide retailer · Per peptide, varies
UK research peptide retailer leaning on UKAS-verified HPLC as the sole-in-UK trust claim. Narrower catalogue than UKPeptides or Pure Peptides UK but the lab-verification angle is the loudest in the segment.
Best for classic peptides catalogue
Research peptide retailer · Per peptide, varies
Long-trading UK research peptide retailer (2012). Heavy on classic compounds (BPC-157, TB-500, GHK-Cu, CJC-1295, Ipamorelin, MOTS-c). No GLP-1, no cosmetic line. CoA gated via on-site contact form (request lab report per product). On-site CusRev reviews 5.0 average, not Trustpilot. Reconstitution calculator on-site.
Buyers who want personal owner-accountability via WhatsApp and prefer CoAs visible in product images rather than gated. Strong stack catalogue.
Research peptide retailer · BPC-157 from £18.99, Wolverine Stack discounted
Family-run Newcastle research peptide retailer (Rian, Victoria, Leah Redman). Owner-fronted WhatsApp on every page. CoAs photographed into the product gallery (COA in image) rather than gated. Heavy on named-stack bundles (Wolverine, Hulk, Ultimate Bundle). Crisp live chat sitewide. Personal accountability is the trust play.
Frequently asked questions
Is NAD+ a peptide?
No. NAD+ is a coenzyme. Most UK research peptide retailers stock it alongside peptides because the audience overlaps.
Is Epitalon evidence-based?
Russian preclinical literature spans four decades. Independent Western replication is sparse. Treat as preliminary, not established.
PeptideClear does not sell, dispense, prescribe, or recommend Longevity Stack for any specific person. This page is editorial commentary on the published preclinical literature and the UK retail landscape. Every research peptide on this page is sold under research-use-only framing.
Read our full methodology and how we are funded.
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