Encyclopedia entry · Longevity
NAD+
Nicotinamide adenine dinucleotide
NAD+ is not a peptide. It is a coenzyme found in every living cell that participates in redox reactions, sirtuin signalling, and DNA repair. Cellular NAD+ levels decline with age across human and animal tissues. UK availability includes oral NAD+ precursor supplements (Nicotinamide Mononucleotide and Nicotinamide Riboside, separate sections), injectable NAD+ stocked by research peptide retailers under research-use-only framing, and intravenous NAD+ infusions offered by some private UK longevity clinics.
What the molecule is
- · Pyridine nucleotide coenzyme. Not a peptide.
- · Central to energy metabolism (NAD+/NADH redox cycle) and sirtuin enzyme activity.
- · Cellular concentrations decline with age in human and animal tissue.
- · UK availability spans oral precursor supplements, research-use injectable, and clinic-administered IV.
What the literature shows
- · Sinclair DA and colleagues on NAD+ in mammalian ageing.
- · Verdin E and colleagues on sirtuin biology and NAD+ availability.
- · Clinical trial work on NMN and NR (NAD+ precursor) oral supplementation.
- · Animal-model evidence for NAD+ restoration in aged tissues.
UK regulatory status
- · Oral NMN and NR are sold as food supplements in the UK under standard food-supplement rules.
- · Injectable NAD+ has no UK marketing authorisation as a medicine.
- · IV NAD+ at private UK clinics is offered as a wellness service, not a licensed medical treatment.
- · Research-use-only framing for non-supplement NAD+ vials sold by research peptide retailers.
Where UK researchers source NAD+
See CoA Trust Index →Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list NAD+ or compounds in the same category. We earn a referral fee when readers click through and convert.
Researchers wanting named-stack bundles (Wolverine, KLOW, Glow) and CoAs that can be QR-verified to a named third-party lab.
Research peptide retailer · Wolverine Stack £29.99, BPC-157 single from £14.99
Nottingham-based research peptide retailer (Bio Research Ltd, since 2024). Bundles and stacks are the hero SKU (Wolverine BPC-157 + TB-500, Tesamorelin + Ipamorelin 3:1, KLOW, Glow). Janoshik third-party CoAs published per batch with QR-code verification. 10-vial bulk packs alongside singles. Wholesale tier above 11 vials.
Best for per-batch CoA library
Research peptide retailer · BPC-157 5mg £13.99, TB-500 5mg £36
Long-established UK research peptide supplier. 12 years trading, 15,000+ customers. Operates a public CoA subdomain (coa.purepeptidesuk.com) with downloadable per-batch certificates linked from every PDP. Dual-tier purity (Standard vs Premium with endotoxin LAL + heavy-metal testing on Premium).
Researchers who want transparent third-party HPLC batch documents and a less hyped brand voice.
Research peptide retailer · Per peptide, varies
UK research peptide retailer with third-party HPLC plus transparent batch documentation. Plays the credibility lane alongside Pure Peptides UK and Tide Labs.
Researchers who weight UKAS lab accreditation specifically and want the loudest external-verification claim in the segment.
Research peptide retailer · Per peptide, varies
UK research peptide retailer leaning on UKAS-verified HPLC as the sole-in-UK trust claim. Narrower catalogue than UKPeptides or Pure Peptides UK but the lab-verification angle is the loudest in the segment.
Best for classic peptides catalogue
Research peptide retailer · Per peptide, varies
Long-trading UK research peptide retailer (2012). Heavy on classic compounds (BPC-157, TB-500, GHK-Cu, CJC-1295, Ipamorelin, MOTS-c). No GLP-1, no cosmetic line. CoA gated via on-site contact form (request lab report per product). On-site CusRev reviews 5.0 average, not Trustpilot. Reconstitution calculator on-site.
Buyers who want personal owner-accountability via WhatsApp and prefer CoAs visible in product images rather than gated. Strong stack catalogue.
Research peptide retailer · BPC-157 from £18.99, Wolverine Stack discounted
Family-run Newcastle research peptide retailer (Rian, Victoria, Leah Redman). Owner-fronted WhatsApp on every page. CoAs photographed into the product gallery (COA in image) rather than gated. Heavy on named-stack bundles (Wolverine, Hulk, Ultimate Bundle). Crisp live chat sitewide. Personal accountability is the trust play.
Where to learn more
- · PubMed search: "NAD+ ageing" and "NMN clinical trial".
- · Sinclair DA lab publications.
- · Our function hub: Longevity peptides.
PeptideClear does not sell, dispense, prescribe, or recommend NAD+ for any specific person. This page is editorial commentary on the published preclinical and clinical research literature and the UK retail landscape.
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UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.