Encyclopedia entry · Sexual Health Peptides

Kisspeptin

Kisspeptin-54, Kisspeptin-10

Kisspeptin is a 54-amino-acid peptide (Kisspeptin-54) that is the primary regulator of GnRH (Gonadotropin-Releasing Hormone) release from the hypothalamus. It sits upstream of the entire hypothalamic-pituitary-gonadal reproductive axis. A 10-amino-acid C-terminal fragment (Kisspeptin-10) retains biological activity. Substantial clinical-trial activity is ongoing in fertility (particularly in vitro fertilisation), Hypoactive Sexual Desire Disorder, and reproductive endocrinology. UK clinical-research lead at Imperial College London (Waljit Dhillo lab).

What the molecule is

· 54-amino-acid peptide encoded by the KISS1 gene.
· Acts on the KISS1R receptor in hypothalamic neurons.
· Stimulates GnRH neuron firing, which drives downstream LH and FSH release from the pituitary.
· Primary regulator of the reproductive endocrine axis in humans and mammals.

What the literature shows

· Clinical trial work in in vitro fertilisation triggering by Imperial College London (Dhillo lab).
· Clinical work in male and female HSDD published by the same group.
· Mechanism work on the role of KISS1 in puberty timing.
· Trial activity in hypothalamic amenorrhoea.

UK regulatory status

· Not a controlled drug under the Misuse of Drugs Act 1971.
· Not scheduled under the Psychoactive Substances Act 2016.
· No UK marketing authorisation as a medicine. Clinical research only.
· UK availability is limited to clinical trial enrolment when a trial is open.
· Research-use-only framing required for any non-trial UK sale.

Where UK researchers source Kisspeptin

See CoA Trust Index →

Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list Kisspeptin or compounds in the same category. We earn a referral fee when readers click through and convert.

Researchers wanting GLP-1-adjacent compounds (Tirzepatide, Retatrutide, Mazdutide) inside a broader peptide catalogue, plus an adjacent biomarker blood-test service.

Peptide Labs UKCoA: partial

Research peptide retailer · BPC-157 £17.99, Tirzepatide from £42.99

Anti-counterfeit-framed UK research peptide retailer leaning hard on Fat Loss as primary nav category (Tirzepatide, Retatrutide, Mazdutide) alongside the broader catalogue. Above 99 percent HPLC and mass-spec verified purity claim. CoA gated by email request. Long-form pillar guides with named author byline and PubMed citations.

Read review Visit

Buyers wanting the broadest catalogue of delivery formats (vials + pens + nasals + capsules + topicals) in the UK segment.

Direct Peptides UKCoA: weak / closed

Research peptide retailer (US parent, UK subdomain) · BPC-157 £11.46 to £189.22 (volume tiers per SKU)

UK-localised subdomain of US-headquartered Direct Peptides (trademark held by Aspire Labs, Texas). Broadest format coverage in the UK segment: lyophilised vials, pre-mixed pens, nasal-spray stacks, capsules, topical cosmetic peptides. 8 years trading (since ~2017). 20 percent first-order discount on dedicated /first-order/ page.

Read review Visit

Where to learn more

· PubMed search: "Kisspeptin clinical trial" and "Kisspeptin-54 reproductive".
· Waljit Dhillo lab publications (Imperial College London).
· Our function hub: Sexual Health peptides.

PeptideClear does not sell, dispense, prescribe, or recommend Kisspeptin for any specific person. This page is editorial commentary on the published preclinical and clinical research literature and the UK retail landscape.

Read our full methodology and how we are funded.

Ready to buy

Buy KISSPEPTIN in the UK

UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.

Compare prices and buy KISSPEPTIN CoA Trust Index