Encyclopedia entry · Sexual Health Peptides
Kisspeptin
Kisspeptin-54, Kisspeptin-10
Kisspeptin is a 54-amino-acid peptide (Kisspeptin-54) that is the primary regulator of GnRH (Gonadotropin-Releasing Hormone) release from the hypothalamus. It sits upstream of the entire hypothalamic-pituitary-gonadal reproductive axis. A 10-amino-acid C-terminal fragment (Kisspeptin-10) retains biological activity. Substantial clinical-trial activity is ongoing in fertility (particularly in vitro fertilisation), Hypoactive Sexual Desire Disorder, and reproductive endocrinology. UK clinical-research lead at Imperial College London (Waljit Dhillo lab).
What the molecule is
- · 54-amino-acid peptide encoded by the KISS1 gene.
- · Acts on the KISS1R receptor in hypothalamic neurons.
- · Stimulates GnRH neuron firing, which drives downstream LH and FSH release from the pituitary.
- · Primary regulator of the reproductive endocrine axis in humans and mammals.
What the literature shows
- · Clinical trial work in in vitro fertilisation triggering by Imperial College London (Dhillo lab).
- · Clinical work in male and female HSDD published by the same group.
- · Mechanism work on the role of KISS1 in puberty timing.
- · Trial activity in hypothalamic amenorrhoea.
UK regulatory status
- · Not a controlled drug under the Misuse of Drugs Act 1971.
- · Not scheduled under the Psychoactive Substances Act 2016.
- · No UK marketing authorisation as a medicine. Clinical research only.
- · UK availability is limited to clinical trial enrolment when a trial is open.
- · Research-use-only framing required for any non-trial UK sale.
Where UK researchers source Kisspeptin
See CoA Trust Index →Ranked by CoA Trust tier (strong, partial, weak). Editorial commentary on retailers that list Kisspeptin or compounds in the same category. We earn a referral fee when readers click through and convert.
Researchers wanting GLP-1-adjacent compounds (Tirzepatide, Retatrutide, Mazdutide) inside a broader peptide catalogue, plus an adjacent biomarker blood-test service.
Research peptide retailer · BPC-157 £17.99, Tirzepatide from £42.99
Anti-counterfeit-framed UK research peptide retailer leaning hard on Fat Loss as primary nav category (Tirzepatide, Retatrutide, Mazdutide) alongside the broader catalogue. Above 99 percent HPLC and mass-spec verified purity claim. CoA gated by email request. Long-form pillar guides with named author byline and PubMed citations.
Buyers wanting the broadest catalogue of delivery formats (vials + pens + nasals + capsules + topicals) in the UK segment.
Research peptide retailer (US parent, UK subdomain) · BPC-157 £11.46 to £189.22 (volume tiers per SKU)
UK-localised subdomain of US-headquartered Direct Peptides (trademark held by Aspire Labs, Texas). Broadest format coverage in the UK segment: lyophilised vials, pre-mixed pens, nasal-spray stacks, capsules, topical cosmetic peptides. 8 years trading (since ~2017). 20 percent first-order discount on dedicated /first-order/ page.
Where to learn more
- · PubMed search: "Kisspeptin clinical trial" and "Kisspeptin-54 reproductive".
- · Waljit Dhillo lab publications (Imperial College London).
- · Our function hub: Sexual Health peptides.
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UK retailers compared by price, Trust Index, and CoA practice. Editorial commentary only. Research use only.